868568-69-8Relevant academic research and scientific papers
A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists
Goodacre, Caroline J.,Bromidge, Steven M.,Clapham, David,King, Frank D.,Lovell, Peter J.,Allen, Mike,Campbell, Lorraine P.,Holland, Vicky,Riley, Graham J.,Starr, Kathryn R.,Trail, Brenda K.,Wood, Martyn D.
, p. 4989 - 4993 (2007/10/03)
Bisaryl cyclic ureas have been identified as high affinity 5-HT 2C receptor antagonists with selectivity over 5-HT2A and 5-HT2B. Compounds such as 8 and 22 have shown oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function in rodents.
