86859-00-9Relevant academic research and scientific papers
USE OF SILVER(I) COMPLEXES AS ANTICANCER AGENTS
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Paragraph 0186, (2017/09/08)
The present invention relates to the use of silver(I) monophosphine complexes as Active Pharmaceutical Ingredients (API's), including anticancer agents, for the treatment, diagnosis and/or prevention of cancer. The present invention also relates to pharmaceutical compositions containing such complexes and further extends to a method of treating or diagnosing a subject/patient suffering from cancer.
USE OF SILVER (I) COMPLEXES AS ANTICANCER AGENTS
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Page/Page column 42, (2013/06/27)
The present invention relates to the use of silver(l) monophosphine complexes as Active Pharmaceutical Ingredients (API's), including anticancer agents, for the treatment, diagnosis and/or prevention of cancer. The present invention also relates to pharmaceutical compositions containing such complexes and further extends to a method of treating or diagnosing a subject/patient suffering from cancer.
Synthesis and characterization of some monomeric and dimeric silver(I)-phosphine complexes with N-donor bridging ligands
Sarkhel, Prashanta,Bhattacharjee, Suchandra,Sarkhel, Sejuti,Chakraborty, Surajit
, p. 1154 - 1157 (2013/01/14)
The monomeric complexes [Ag(PPh3)2]X (X = ClO 4 - or NO3) was synthesized by a metathesis reaction of [Ag2(PPh3)4(μ-SO4)] with BaX2 (where X = ClO4 - or NO3 -) in ethanol. The reactivity of [Ag(PPh3)2]X (where X = ClO4 - or NO3 -) with some potential N-donor bridging ligands viz. 4,4 bipyridine and pyrazine yielded dimeric complexes of the type [Ag2(PPh3) 4(μ-L-L)]X2 (where L-L = 4,4-bipyridine or pyrazine, and X = ClO4 - or NO3 -). All these complexes were characterized by infrared spectroscopy, conductivity measurements, cyclic voltammetry, 1H NMR, and electronic spectroscopy.
Synthesis, characterization and antimicrobial studies of mixed ligand silver(I) complexes of thioureas and triphenylphosphine; crystal structure of {[Ag(PPh3)(thiourea)(NO3)]2·[Ag( PPh3)(thiourea)]2(NO3)2}
Isab, Anvarhusein A.,Nawaz, Sidra,Saleem, Muhammad,Altaf, Muhammad,Monim-ul-Mehboob, Muhammad,Ahmad, Saeed,Evans, Helen Stoeckli
, p. 1251 - 1256 (2010/05/01)
Mixed ligand silver(I) complexes of triphenylphosphine and thioureas (thiourea (Tu), N-methylthiourea (Metu), N,N′-dimethylthiourea (Dmtu) and N,N′-diethylthiourea (Detu)) with the general formulae, [(Ph3P)2Ag(thione)]NO3 and [(Ph3P)Ag(thione)2]NO3, have been prepared and characterized by elemental analysis, IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure of one of them has been determined by X-ray crystallography. The spectral data of the complexes are consistent with sulfur coordination of the thiones to silver(I). The single crystal X-ray structure of complex 1, {[Ag(PPh3)(thiourea)(NO3)]2·[Ag( PPh3)(thiourea)]2(NO3)2}, shows that the complex consists of two independent centrosymmetric binuclear units, each having the silver atoms coordinated to one PPh3 and two bridging thiourea molecules. In one of the independent units the silver atom is additionally bound to a nitrate ion, leading to a tetrahedral geometry, while in the other unit the silver atom adopts a trigonal planar environment. Antimicrobial activities of the complexes were evaluated by their minimum inhibitory concentration and the results showed that the complexes show a wide range of activity against two gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and molds (Aspergillus niger, Penicillium citrinum), while the activities were poor against yeasts (Candida albicans, Saccharomyces cerevisiae). However, the title complex did not show activity against any tested microorganism.
Syntheses and structures of silver(I) and palladium(II) complexes with ferrocenyl-phosphonodithiolate ligands
Wang, Xi-Ying,Shi, Hua-Tian,Ma, Qing,Zhang, Qian-Feng
, p. 32 - 36 (2010/05/02)
Coordinative interaction of [Ag(PPh3)2NO3] or [Pd(MeCN)2Cl2] with in situ-prepared Na[FcP-(OR)S 2] afforded 1 : 1 products [FcP(OR)S2Ag(PPh 3)2] (R = Me 1,
Synthesis of New Heterodinuclear Aminocarbyne Complexes: Crystal Structures of(C6F5)(CO)2-(η-C5H5)> and Cl(CO)2(η-C5H5)>2>
Albano, Vincenzo G.,Busetto, Luigi,Cassani, Maria Cristina,Sabatino, Piera,Schmitz, Arndt,Zanotti, Valerio
, p. 2087 - 2094 (2007/10/02)
The aminocarbyne CN(Et)Me>(CO)2(cp)> 1 (cp = η-C5H5) reacts with (tht = tetrahydrothiophene) and CuCl to give the adducts (C6F5)(CO)2(cp)> 2 and Cl(CO)2(cp)>2> 3 respectively which have been structurally characterized by X-ray diffraction.Complex 2 crystallizes in space group P, a = 9.840(5), b = 11.577(6), c = 8.296(6) Angstroem, α = 99.03(5), β = 91.01(6), γ = 81.92(4) deg, Z = 2.Complex 3 crystallizes in space group P21/a, a = 7.788(2), b = 14.880(5), c = 11.712(5) Angstroem, β = 95.35(3) deg , Z = 2.Both adducts exhibit a molecule of 1 bonded to Au(C6F5) or Cu2Cl2 fragments, respectively, through one of the W-C(carbyne) ? bonds.A WCM ring is formed in which 1 preserves most of its identity and the coinage metals attain their preferred electron counts.The cationic Group 11 fragments (M = Cu, Ag or Au) also react with complex 1 to form (CO)2(cp)>2>(1+) 5; when M = Au NMR spectroscopy indicates that in addition to the trinuclear species 5, the dimetallacyclopropene (CO)2(cp)(PPh3)>(1+) 4 is also present.All these adducts have been spectroscopically characterised.
Lewis Base Adducts of Group 11 Metal Compounds. Part 24. Co-ordination of Triphenylphosphine with Silver Nitrate. A Solid-state Cross-polarisation Magic Angle Spinning 31P Nuclear Magnetic Resonance, Crystal Structure, and Infrared Spectroscopic Study of Ag(PPh3)nNO3 (n=1-4)
Barron, Peter F.,Dyason, Jeffery C.,Healy, Peter C.,Engelhardt, Lutz M.,Skelton, Brian W.,White, Allan H.
, p. 1965 - 1970 (2007/10/02)
Solid-state cross-polarisation magic angle spinning 31P n.m.r. spectroscopy, single-crystal X-ray stucture determination, and i.r. spectroscopy have been used to investigate the properties of the adducts of triphenylphosphine with silver(I) nitrate: Ag(PPh3)NO3, (1); Ag(PPh3)2NO3, (2); Ag(PPh3)3NO3, (3) and Ag(PPh3)4NO3, (4).The value of 1J(Ag-P) decreases with increasing co-ordination number: (1), 780; (2), 470; (3), 310; and (4), 190 Hz, paralleling solution results.Single-crystal X-ray structure determinations of compounds (2)-(4) have been performed: (2), triclinic, space group P1, a=11.821(3), b=11.990(3), c=13.660(3) Angstroem, α=102.05(2), β=112.80(2), and γ=105.30(2) deg, yielding R=0.036 for 4090 'observed' reflections; Ag-P 2.443(1) and 2.440(1) Angstroem, P-Ag-P 138.21(5) deg; (3), monoclinic, space group P21/n, a=18.984(5), b=13.710(3), c=17.900(4) Angstroem, and β=94.94(2) deg, yielding R=0.053 for 5126 reflections; Ag-P 2.630(2), 2.525(1), and 2.545(2) Angstroem, P-Ag-P 118.37(5), 112.07(4), and 116.44(5) deg; (4), trigonal, space group R3, a=19.07(2) Angstroem, and α=43.77(5) deg, yielding R=0.060 for 1903 observed reflections; Ag-P 2.643(3) and 2.671(4) Angstroem, P-Ag-P 109.49(12) and 109.45(10) deg.Structures (2) and (3) are isomorphous with the analogous triphenylarsine compounds.In all cases the nitrate group is only weakly co-ordinated : Ag-O 2.464(4) and 2.649(4) in (2), 2.684(6) and 2.775(6) Angstroem in (3).These weak interactions are reflected in the small splitting observed for the asymmetric N-O streching vibrational mode compared to the analogous copper(I) compounds.
