868602-86-2

Basic information

• Product Name: Acetamide, N-methyl-N-[1-(4-methylphenyl)ethenyl]-
• Synonyms: Acetamide, N-methyl-N-[1-(4-methylphenyl)ethenyl]-
• CAS NO: 868602-86-2
• Molecular Formula: C12H15NO
• Molecular Weight: 189.25
• Mol File: 868602-86-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetamide, N-methyl-N-[1-(4-methylphenyl)ethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-methyl-N-[1-(4-methylphenyl)ethenyl]-(868602-86-2)
• EPA Substance Registry System: Acetamide, N-methyl-N-[1-(4-methylphenyl)ethenyl]-(868602-86-2)

Safety Data

• Hazardous Substances Data: 868602-86-2(Hazardous Substances Data)

Upstream product

• 122-00-9 para-methylacetophenone 
• 177750-08-2 1-(4-methylphenyl)ethenylacetamide 
• 2089-33-0 4-methylacethophenone oxime 
• 74-88-4 methyl iodide 
• 3195-78-6 N-vinyl-N-methylacetamide 
• 106-38-7 para-bromotoluene 

Relevant articles and documents

Visible-light-promoted olefinic trifluoromethylation of enamides with CF3SO2Na

A visible-light-promoted olefinic C-H trifluoromethylation of enamides was developed by employing cheap and stable Langlois’ reagent as the CF3source. A series of β-CF3enamides were obtained in moderate to good yields with highE-isomer selectivity under mild conditions. Preliminary mechanistic studies suggest that molecular oxygen acts as the terminal oxidant for this net oxidative process, and theEisomer selectivity could be well explained by a base-assisted deprotonation of the cation intermediate.

PALLADIUM CATALYSED HECK ARYLATION OR VINYLATION OF 1-SUBSTITUTED OLEFINS

The present invention relates to a process for preparing arylated or vinylated olefins.

Palladium-catalyzed regioselective Heck arylation of electron-rich olefins in a molecular solvent-ionic liquid cocktail

We have recently established that highly regioselective Heck arylation of electron-rich olefins can be accomplished with aryl halides without using any halide scavengers in imidazolium ionic liquid solvents. The results presented in this paper show that the benchmark electron-rich olefins vinyl ethers can be readily arylated by aryl bromides in a molecular solvent-ionic liquid cocktail with no compromise on regioselectivity. By introducing a small amount of 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]) to DMSO, the arylation reactions of the vinyl ethers 1a-d by the bromides 2a-j took place to afford essentially only the α arylated products. The enamide 1e underwent similar regioselective arylation in the solvent cocktail. In the absence of the ionic liquid, lower regioselectivities were observed. In comparison with the chemistry we have reported so far, the current method reduces considerably the reliance on the volume of ionic liquids used, providing a simpler and more practical synthetic pathway for preparing arylated vinyl ethers and aryl methyl ketones.