868615-18-3

Basic information

• Product Name: 2-chloromethyl-3,4,5-trimethoxytoluene
• Synonyms: 2-chloromethyl-3,4,5-trimethoxytoluene
• CAS NO: 868615-18-3
• Molecular Weight: 230.691
• Mol File: 868615-18-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloromethyl-3,4,5-trimethoxytoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloromethyl-3,4,5-trimethoxytoluene(868615-18-3)
• EPA Substance Registry System: 2-chloromethyl-3,4,5-trimethoxytoluene(868615-18-3)

Safety Data

• Hazardous Substances Data: 868615-18-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 6443-69-2 3,4,5-trimethoxytoluene 

Downstream Products

• 1082823-35-5 2-chloromethyl-6-hydroxyl-3,4,5-trimethoxytoluene 

Relevant articles and documents

A convenient synthesis of N-benzylpiperazine, 1-aralkyl-4-benzylpiperazines and an Isostere of Idebenone

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Novel intermediates, process for their preparation and synthesis of 1, 4-benzoquiones

The present invention discloses a new process for the preparation of 1,4-benzoquiones of formula (II) wherein R1, R2, R3 and R4 are independently selected from the group consisting of branched or unbranched C1-C6 alkyl, phenyl and benzyl, wherein phenyl and benzyl is optionally substituted by one or more substituent independently selected from the group consisting of C1-C6 alkyl and halogen, and wherein C1-C6 alkyl is optionally substituted with one or more halogen susbstituents, and wherein R2 and R3 together can form a C1-C6-alkylene radical, optionally substituted by one or more susbstituents independently selected from the group comprising C1-C6, benzyl, phenyl and halogen. One preferred compound is 2,3-dimethoxy-5-methyl-[1,4]benzoquinone, also known as coenzyme Q0 (CoQ0). Also disclosed are novel compounds and intermediates, and a method for the preparation of coenzyme Qn, preferable the coenzyme Q10. Also disclosed is a method for continuous synthesis of 1,4-benzoquiones in a continuous flow reactor.