868622-70-2Relevant academic research and scientific papers
Design and synthesis of phthalimide-type histone deacetylase inhibitors
Shinji, Chihiro,Nakamura, Takanori,Maeda, Satoko,Yoshida, Minoru,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 4427 - 4431 (2007/10/03)
Several hydroxamic acid derivatives with a substituted phthalimide group as a linker and/or cap structure, prepared during structural development studies based on thalidomide, were found to have histone deacetylase (HDAC)-inhibitory activity. Structure-activity relationship studies indicated that nature of the substituent introduced at the phthalimide nitrogen atom, introduction of a hydroxamic acid structure, and distance between the N-hydroxyl group and the cap structure are important for HDAC-inhibitory activity.
