868628-76-6

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 194352-59-5 4-oxo-4-(1-tosyl-1H-pyrrol-3-yl)butanoic acid 

Downstream Products

• 1449650-39-8 1-tosyl-1,4,5,10-tetrahydropyrrolo[2,3-a]carbazole 
• 1449650-40-1 1-tosyl-1,10-dihydropyrrolo[2,3-a]carbazole 
• 63814-03-9 1,2,3,3a,4,5,12b,12c-octahydro-7H-1,3-benzodioxolo[5,6-c]pyrrolo[3,2,1-ij]quinoline 

Relevant academic research and scientific papers

Synthesis of (±)-γ-Lycorane by Using an Intramolecular Friedel-Crafts Reaction

A total synthesis of γ-lycorane has been achieved by employing N -tosylpyrrole as a key building block. The synthesis employs both an intermolecular and an intramolecular Friedel-Crafts reaction, as well as a completely diastereoselective hydrogenation of

A novel necroptosis inhibitor - Necrostatin-21 and its SAR study

An initial structure-activity relationship study of the novel necroptosis inhibitor Nec-21 was described. Any changes of the tetracyclic scaffold were detrimental for the activity. Introduction of a substituent to 7 or 8 position (e.g., cyano or methoxy group, respectively), would increase the activity. The 7 and 8-position disubstituted compound 17b was 35-fold as potent as the lead, while EC50 reached 14 nM.