868634-14-4

Upstream product

• 868633-96-9 1-allyl-5-[1-((4R,5S)-2,2-dimethyl-5-phenyl[1,3]dioxolan-4-yl)methanoyl]-2-methyl-1,5,6,7-tetrahydro-benzoimidazol-4-one 

Downstream Products

• 868634-18-8 (6R,7S,8R)-3-allyl-6-hydroxy-2-methyl-8-phenyl-7-pivaloxy-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole 

Relevant academic research and scientific papers

6,7-DIHYDROXY-8-PHENYL-3,6,7,8-TETRAHYDRO-CHROMENO[7, 8-D]IMIDAZOLE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS

The invention provides compounds of formula (1), in which R1 is hydrogen, halogen, 1-4C-alkyl, 3-7-Ccycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4-alkoxy, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxycarbonyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl or hydroxy-1-4C-alkyl, R2 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-1-4C-alkyl or hydroxy-1-4C-alkyl, R3 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, fluoro-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl or hydroxy-1-4C-alkyl, R4 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, fluoro-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl, hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkylcarbonyl, mono- or di-1-4C-alkylamino-1-4C-alkylcarbonyl or 1-4C-alkylcarbonyl or where R3 and R4 together form a methylen (-CH2-), an ethylen (-CH2-CH2-), a propylen (-CH2-CH2-CH2-) or an isopropylidene (-C(-CH3)2-) radical, R5 is hydrogen, halogen, 1-4C-alkyl or fluoro-1-4C-alkyl, R6 is hydrogen, halogen, 1-4C- alkyl or fluoro-1-4C-alkyl, and the salts of these compounds. The compounds inhibit the secretion of gastric acid.