868635-12-5Relevant academic research and scientific papers
Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics
Chruma, Jason J.,Liu, Lei,Zhou, Wenjun,Breslow, Ronald
, p. 5873 - 5883 (2005)
The first functional catalytic mimic of the enzyme dialkylglycine decarboxylase is described. This system utilizes a hydrophobically modified polyethylenimine polymer, a pyridoxamine cofactor, and a 2-aryl-2-alkylglycine sacrificial amine source to convert α-keto acids to α-amino acids at biologically relevant temperatures with multiple turnovers of the pyridoxamine catalyst. The effects of hydrophobic and electronic factors in the 2,2-disubstituted sacrificial amine source and the pyridoxamine catalyst on turnover frequency and turnover number are explored.
