868662-02-6

Basic information

• Product Name: [(S)-1-(5-bromopyridin-2-yl)pyrrolidin-3-yl]dimethylamine
• Synonyms: [(S)-1-(5-bromopyridin-2-yl)pyrrolidin-3-yl]dimethylamine
• CAS NO: 868662-02-6
• Molecular Formula: C₁₁H₁₆BrN₃
• Molecular Weight: 270.17
• Mol File: 868662-02-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(S)-1-(5-bromopyridin-2-yl)pyrrolidin-3-yl]dimethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-1-(5-bromopyridin-2-yl)pyrrolidin-3-yl]dimethylamine(868662-02-6)
• EPA Substance Registry System: [(S)-1-(5-bromopyridin-2-yl)pyrrolidin-3-yl]dimethylamine(868662-02-6)

Safety Data

• Hazardous Substances Data: 868662-02-6(Hazardous Substances Data)

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 766-11-0 5-bromo-2-fluoropyridine 
• 223463-13-6 2-iodo-5-bromopyridine 

Relevant articles and documents

BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and/or diabetes.

NOVEL MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.

A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties

Melanin-concentrating hormone receptor antagonists containing thieno- and a benzopyridazinone cores were designed and tested as potential anorectic agents. These ligands showed high affinity for the receptor, potent functional activity in vitro, and good oral bioavailability in rats. The thiophene analogue exhibited low iv clearance, long half-life, and high brain penetration. In obese rats, the thienopyridazinone demonstrated a dose-dependent reduction in feeding and body weight with doses between 1 and 10 mg kg-1.

2- (3-AMINOPYRROLIDIN-1-YL) PYRIDINES AS MELANIN-CONCENTRATING HORMONE RECEPTOR AN TAGONISTS

Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R5, Het, X and Cyc are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.