868662-07-1Relevant articles and documents
Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists
Dyck, Brian,Zhao, Liren,Tamiya, Junko,Pontillo, Joseph,Hudson, Sarah,Ching, Brett,Heise, Christopher E.,Wen, Jenny,Norton, Christi,Madan, Ajay,Schwarz, David,Wade, Warren,Goodfellow, Val S.
, p. 4237 - 4242 (2007/10/03)
A series of substituted chromones were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor 1. Compounds with subnanomolar binding affinity and 66% oral bioavailability in rats were discovered.