868663-78-9

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 13242-53-0 acetobromomannose 
• 630102-81-7 3,4,6-Tri-O-acetyl-1,2-O-<(R,S)-ethylidene>-β-D-mannopyranose 
• 230953-16-9 1,2-O-ethylidene-(R,S)-β-D-mannopyranose 
• 324041-33-0 4,6-O-Benzylidene-1,2-O-ethylidene-β-D-mannopyranose 

Relevant academic research and scientific papers

Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose

The mannose monosaccharide derivative, acetylthiopropyl 2,3,4,6-tetra-O-acetyl-α-d-mannopyranoside (Man), and the mannobiose derivative, acetylthiopropyl 2,4,6-tri-O-acetyl-3-O-(2′,3′,4′, 6′-tetra-O-acetyl-α-d-mannopyranosyl)-α-d-mannopyranoside (α-1,3-Man), were synthesized respectively. These mannose derivatives were introduced into carbosilane dendrimer scaffolds of the zero and first generations. As a result, six carbosilane dendrimers were functionalized by Man and α-1,3-Man. Isothermal titration microcalorimetry was done to determine binding assay between mannose moieties of carbosilane dendrimer and concanavalin A. It was found that carbosilane dendrimers bound more efficiently to concanavalin A than free mannose (Me-α-Man) and mannobiose (Me-α-1,3-Man).