868670-42-2Relevant academic research and scientific papers
Synthesis of 2,6-disubstituted piperidine-bearing α-amino acid side-chains
Boeglin, Damien,Heitz, Annie,Martinez, Jean,Fehrentz, Jean-Alain
, p. 3139 - 3146 (2007/10/03)
A straightforward synthesis of 2,6-disubstituted piperidines bearing α-amino acid side-chains was developed. Synthesis was based on a Horner-Wadsworth-Emmons condensation of a β-ketophosphonate derived from an α-amino acid residue with a β-homologated ald
Peptidyl β-homo-aspartals: Specific inhibitors of interleukin-1β converting enzyme and its homologues (caspases)
Bajusz, Sandor,Fauszt, Iren,Nemeth, Klara,Barabas, Eva,Juhasz, Attila,Patthy, Miklos
, p. 1477 - 1482 (2007/10/03)
Inhibition of interleukin-1β convening enzyme (ICE), apopain, papain, thrombin and trypsin with substrate like peptidyl L- and D-α-aldehydes and their L-β-homo-aldehyde analogues was investigated. The L-β-homo-aspartals appear to be specific inhibitors fo
