868686-01-5Relevant academic research and scientific papers
Synthesis, Radiosynthesis, and Biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: Potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter
Zeng, Fanxing,Mun, Jiyoung,Jarkas, Nachwa,Stehouwer, Jeffrey S.,Voll, Ronald J.,Tamagnan, Gilles D.,Howell, Leonard,Votaw, John R.,Kilts, Clinton D.,Nemeroff, Charles B.,Goodman, Mark M.
experimental part, p. 62 - 73 (2009/09/29)
Reboxetine analogues with methyl and fluoroalkyl substituents at position 2 of the phenoxy ring 1-4 were synthesized. In vitro competition binding with [3H]nisoxetine demonstrated that 1-4 have a high affinity for the norepinephrine transporter
Substituted morpholine compounds for the treatment of central nervous system disorders
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Page/Page column 43, (2010/02/14)
This invention relates to compounds of the formulae I wherein R1-R8, A, X, and Z are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.
