868699-56-3Relevant academic research and scientific papers
Identification of 1-[4-benzyloxyphenyl)-but-3-enyl]-1H-azoles as new class of antitubercular and antimicrobial agents
Anand, Namrata,Ramakrishna,Gupt, Munna P.,Chaturvedi, Vinita,Singh, Shubhra,Srivastava, Kishore K.,Sharma, Prapunjika,Rai, Niyati,Ramachandran, Ravishankar,Dwivedi,Gupta, Varsha,Kumar, Brijesh,Pandey, Smriti,Shukla, Praveen K.,Pandey, Shailandra K.,Lal, Jawahar,Tripathi, Rama Pati
, p. 958 - 963 (2013/10/22)
A series of 1-[(4-benzyloxyphenyl)-but-3-enyl]-1H-azoles has been identified as potent antitubercular agents against Mycobacterium tuberculosis. Synthesis of compounds involved acid catalyzed ring-opening of cyclopropyl ring of phenyl cyclopropyl methanols followed by nucleophilic attack of the azoles on the carbocation intermediates. Several of the compounds 26, 34, and 36 exhibited significant antitubercular activities with MIC value as low as 1.56, 1.56, and 0.61 μg/mL, respectively, comparable to many standard drugs. These compounds were also screened against other strains of bacteria and fungi, and few of them showed good antifungal activity against A. fumigatus, responsible for lung infection.
An efficient synthesis of aryloxyphenyl cyclopropyl methanones: A new class of anti-mycobacterial agents
Dwivedi, Namrata,Tewari, Neetu,Tiwari,Chaturvedi, Vinita,Manju,Srivastava,Giakwad,Sinha,Tripathi
, p. 4526 - 4530 (2007/10/03)
An efficient, high yield and one-pot synthesis of phenyl cyclopropyl methanones by reaction of different aryl alcohols with 4′-fluoro-4-chloro- butyrophenone in THF/DMF in the presence of NaH/TBAB is reported. Most of the methanones were further reduced t
