868733-45-3Relevant academic research and scientific papers
Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors
Zhao, Yanmei,Zhang, Jiankang,Zhuang, Rangxiao,He, Ruoyu,Xi, Jianjun,Pan, Xuwang,Shao, Yidan,Pan, Jinming,Sun, Jingjing,Cai, Zhaobin,Liu, Shourong,Huang, Weiwei,Lv, Xiaoqing
, p. 3195 - 3205 (2017/05/25)
In this study, a series of novel pyridine and pyrimidine-containing derivatives were designed, synthesized and biologically evaluated for their c-Met inhibitory activities. In the biological evaluation, half of the target compounds exhibited moderate to p
Discovery of novel c-met inhibitors bearing a 3-carboxyl piperidin-2-one scaffold
Zhang, Wei,Ai, Jing,Shi, Dakuo,Peng, Xia,Ji, Yinchun,Liu, Jian,Geng, Meiyu,Li, Yingxia
, p. 2655 - 2673 (2014/03/21)
A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines. The results indi
New aminopyrimidine derivatives as inhibitors of the TAM family
Traoré, Ténin,Cavagnino, Andrea,Saettel, Nicolas,Radvanyi, Fran?ois,Piguel, Sandrine,Bernard-Pierrot, Isabelle,Stoven, Véronique,Legraverend, Michel
, p. 789 - 801 (2013/12/04)
In this study, we describe the synthesis of new pyrimidine analogs of BMS-777607, a potent and selective inhibitor of Met kinase. Inhibition of Met and Axl remained high whereas inhibition of Tyro3 and Mer decreased to some extend. The preferential modera
Monocyclic heterocycles as kinase inhibitors
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Page/Page column 32, (2008/06/13)
The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.
