86879-53-0Relevant academic research and scientific papers
Synthesis and Photochemistry of a New Class of Photocleavable Protein Cross-linking Reagents
Milanesi, Lilia,Reid, Gavin D.,Beddard, Godfrey S.,Hunter, Christopher A.,Waltho, Jonathan P.
, p. 1705 - 1710 (2004)
A new series of photocleavable protein cross-linking reagents based on bis(maleimide) derivatives of diaryl disulfides have been synthesised. They have been functionalised with cysteine and transient absorption spectra for the photolysis reaction have been recorded by using the pump-probe technique with a time resolution of 100 femtoseconds. Photolysis of the disulfide bond yields the corresponding thiyl radicals in less than a picosecond. There is a significant amount of geminate recombination, but some of the radicals escape the solvent cage and the quantum yield for photocleavage is 30% in water.
Synthesis of new bis(tetrahydropyrrolo[3,4-b]carbazoles) with a functionalized diaryl spacer
Mehrabani,Pindur
, p. 1406 - 1412 (2007/10/03)
Some new bis(tetrahydropyrrolo[3,4-b]carbazoles) were synthesized by Diels-Alder reactions of in-situ generated indole-2,3-quinodimethanes with a variety of bismaleimides as dienophiles and also by reaction of dianilines with a succinic acid anhydride group incorporated into a biscarbazole. In a special reaction a spermine linker was introduced. The new biscarbazoles represent potential DNA ligands for the development of new antitumor active drugs.
