868835-85-2Relevant academic research and scientific papers
HISTONE DEACETYLASE INHIBITORS
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Page/Page column 47, (2008/06/13)
The present invention provides novel HDAC inhibitors and methods of treating diseases using the same.
Alkyl-substituted polyaminohydroxamic acids: A novel class of targeted histone deacetylase inhibitors
Varghese, Sheeba,Gupta, Deepak,Baran, Tiffany,Jiemjit, Anchalee,Gore, Steven D.,Casero Jr., Robert A.,Woster, Patrick M.
, p. 6350 - 6365 (2007/10/03)
The reversible acetylation of histones is critical for regulation of eukaryotic gene expression. The histone deacetylase inhibitors trichostatin (TSA, 1), MS-275 (2) and suberoylanilide hydroxamic acid (SAHA, 3) arrest growth in transformed cells and in h
