868851-35-8

Basic information

• Product Name: 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;Ethyl 5-Methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazole-4-carboxylate
• CAS NO: 868851-35-8
• Molecular Formula: C₁₄H₁₃F₃N₂O₃
• Molecular Weight: 314.26
• Mol File: 868851-35-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(868851-35-8)
• EPA Substance Registry System: 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(868851-35-8)

Safety Data

• Hazardous Substances Data: 868851-35-8(Hazardous Substances Data)

Upstream product

• 36823-88-8 4-(trifluoromethoxy)benzoyl chloride 
• 623-49-4 ethyl cyanoformate 
• 93919-56-3 4-(trifluoromethoxy)benzyl amine 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 

Downstream Products

• 868851-36-9 5-methyl-2-(4-trifluoromethoxy-phenyl)-1H-imidazole-4-carboxylic acid 

Relevant articles and documents

Synthesis of di- and tri-substituted imidazole-4-carboxylates via PBu3-mediated [3+2] cycloaddition

Some new di- and trisubstituted imidazole-4-carboxylates were prepared from amidoacetic acids 3 in the present report. The key step to establish such imidazole- 4-carboxylates stemmed from the PBu3-mediated [3+2] cycloaddition between in situ-generated Δ2-oxazolinone 4 and ethyl cyanoformate6. Our results indicated that trisubstituted imidazoles 7-20 were afforded in better yields than those of disubstituted imidazoles 21-27. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.