868993-06-0Relevant academic research and scientific papers
A practical synthesis of m-prostaglandin E synthase-1 inhibitor MK-7285
Gosselin, Francis,Lau, Stephen,Nadeau, Christian,Trinh, Thao,O'Shea, Paul D.,Davies, Ian W.
scheme or table, p. 7790 - 7797 (2010/03/05)
(Chemical Equation Presented) A practical, kilogram-scale chromatography-free synthesis of mPGE synthase I inhibitor MK-7285 is described. The route features a convergent assembly of the core phenanthrene unit via amide-directed ortho-metalation and proxi
TETRACYCLIC INHIBITORS OF JANUS KINASES
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Page/Page column 61, (2008/06/13)
The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
