869062-77-1Relevant academic research and scientific papers
Asymmetric Michael addition reactions catalyzed by calix[4]thiourea cyclohexanediamine derivatives
Li, Zheng-Yi,Tong, Hong-Xiao,Chen, Yuan,Su, Hong-Kui,Xiao, Tangxin,Sun, Xiao-Qiang,Wang, Leyong
supporting information, p. 1901 - 1907 (2018/08/21)
A number of upper rim-functionalized calix[4]thiourea cyclohexanediamine derivatives have been designed, synthesized and used as catalysts for enantioselective Michael addition reactions between nitroolefins and acetylacetone. The optimal catalyst 2 with
Calix[4]thiourea diaminocyclohexane derivatives and method thereof for catalyzing asymmetric Michael addition
-
Paragraph 0051; 0052; 0054; 0055, (2018/11/22)
The invention relates to calix[4]thiourea diaminocyclohexane derivatives and a method thereof for catalyzing asymmetric Michael addition. An Michael addition catalytic reaction is performed on nitroolefin and 1,3-dicarbonyl ketone as raw materials, the ca
Ferrocene as a scaffold for effective bifunctional amine-thiourea organocatalysts
Yao, Wei,Chen, Ming,Liu, Xueying,Jiang, Ru,Zhang, Shengyong,Chen, Weiping
, p. 1726 - 1729 (2014/06/09)
A simple and readily accessible prototype of the ferrocene-based bifunctional amine-thioureas shows high enantioselectivity in the Michael addition of acetylacetone to nitroolefins, giving the enantioselectivity of up to 96% ee. This work demonstrates tha
Chiral squaramide as multiple H-bond donor organocatalysts for the asymmetric Michael addition of 1,3-dicarbonyl compounds to nitroolefins
Dong, Ze,Qiu, Guofu,Zhou, Hai-Bing,Dong, Chune
, p. 1550 - 1556 (2013/02/21)
A series of chiral bifunctional squaramide multiple H-bond donor organocatalysts have been designed and synthesized by the rational assembly of chiral privileged scaffolds of indanol and cinchona alkaloids. In the presence of 1 mol % 1a, the asymmetric Mi
Novel carbohydrate-based bifunctional organocatalysts for nucleophilic addition to nitroolefins and imines
Puglisi, Alessandra,Benaglia, Maurizio,Raimondi, Laura,Lay, Luigi,Poletti, Laura
experimental part, p. 3295 - 3302 (2011/05/30)
Glucosamine has been selected as a cheap and readily available chiral scaffold for the synthesis of a series of novel enantiomerically pure bifunctional organocatalysts bearing a tertiary amino group in proximity to a (thio)urea group. The catalytic behav
Highly efficient and enantioselective Michael addition of acetylacetone to nitroolefins catalyzed by chiral bifunctional organocatalyst bearing multiple hydrogen-bonding donors
Shi, Xin,He, Wei,Li, Hua,Zhang, Xu,Zhang, Shengyong
scheme or table, p. 3204 - 3207 (2011/06/28)
A new efficient catalyst system for the asymmetric addition of acetylacetone to nitroolefins using a chiral bifunctional organocatalyst bearing multiple hydrogen-bonding donors was developed. When using the organocatalyst 2c derived from natural cinchona alkaloid in optimal conditions, up to 98% chemical yield and 98% ee were observed with a variety of aromatic nitroolefins.
Sugar-derived bifunctional thiourea organocatalyzed asymmetric Michael addition of acetylacetone to nitroolefins
Gao, Peng,Wang, Chungui,Wu, Yang,Zhou, Zhenghong,Tang, Chuchi
supporting information; experimental part, p. 4563 - 4566 (2009/05/07)
A bifunctional chiral thiourea organocatalyst bearing a glycosyl scaffold and a tertiary amino group proved to be an effective organocatalyst for the asymmetric Michael addition of acetylacetone to nitroolefins. The corresponding adducts were obtained in
