869103-47-9Relevant academic research and scientific papers
Chemoenzymatic formal total synthesis of (-)-bestatin
Feske, Brent D.,Stewart, Jon D.
, p. 3124 - 3127 (2007/10/03)
A highly stereoselective, enzymatic reduction of an α-chloro-β- keto ester provided the key intermediate for a total synthesis of the α-hydroxy-β-amino acid moiety of (-)-bestatin. The reduction product was cyclized to a glycidic ester that was opened in a Ritter reaction with benzonitrile, affording a trans-oxazoline, which was hydrolyzed under acidic conditions to the target molecule.
