869109-01-3Relevant academic research and scientific papers
Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators
Bridges, Thomas M.,Kennedy, J. Phillip,Hopkins, Corey R.,Conn, P. Jeffrey,Lindsley, Craig W.
scheme or table, p. 5617 - 5622 (2010/11/05)
This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M5-preferring positive allosteric modulator (PAM), discovered through analog work around VU0119498, a pan Gq mAChR M1, M3, M5 PAM. An iterative parallel synthesis approach was employed to incorporate basic heterocycles to improve physiochemical properties.
IMIDAZOPYRIDINE COMPOUND
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Page/Page column 48, (2008/06/13)
The present invention provides an imidazopyridine compound represented by formula (I), wherein R1 and R2 each independently represent a C1-6 alkyl group et al; R3 and R4 each independently represent a hydrogen atom, a methyl et al; Ar1 is a divalent substituent representing a monocyclic or bicyclic, 3- to 8-membered aromatic or aliphatic heterocyclic group et al; Ar2 represents an aromatic carbocyclic group, or an aromatic heterocyclic group; W represents -(CH2)m et al, and m indicates an integer of from 0 to 10. This compound acts as a melanin concentrating hormone receptor antagonist, and is useful as treating agents for obesity.
