86911-88-8

Basic information

• Product Name: 3-(2,5-Dimethoxy-phenyl)-7-methoxy-3H-isobenzofuran-1-one
• Synonyms: 3-(2,5-Dimethoxy-phenyl)-7-methoxy-3H-isobenzofuran-1-one
• CAS NO: 86911-88-8
• Molecular Weight: 300.311
• Mol File: 86911-88-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(2,5-Dimethoxy-phenyl)-7-methoxy-3H-isobenzofuran-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,5-Dimethoxy-phenyl)-7-methoxy-3H-isobenzofuran-1-one(86911-88-8)
• EPA Substance Registry System: 3-(2,5-Dimethoxy-phenyl)-7-methoxy-3H-isobenzofuran-1-one(86911-88-8)

Safety Data

• Hazardous Substances Data: 86911-88-8(Hazardous Substances Data)

Upstream product

• 2886-59-1 1-methoxycyclohexa-1,4-diene 
• 86911-85-5 ethyl 4-(2,5-dimethoxyphenyl)-4-hydroxy-2-butynoate 
• 6833-21-2 2-methoxy-N-phenylbenzamide 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Downstream Products

• 2961-04-8 1,4,5-trihydroxy-9,10-anthracenedione 
• 408356-72-9 1-(2,5-dimethoxy-phenyl)-4-methoxy-1,3-dihydro-isobenzofuran 
• 64831-62-5 2-<2,5-Dimethoxy-benzoyl>-6-methoxy-benzoesaeure 

Relevant articles and documents

Application of organolithium and related reagents in synthesis. Part 25: Novel specific synthesis of the 4-arylisochroman-3-acetic acids via conversion of benzoic acids

The transformation of the benzanilides 1 into 4-arylisochroman-3-acetic acids 8 applying the following sequence of reactions is described. At first, the 3-arylphthalides 3 were obtained via metallation [n-BuLi] of benzanilides 1 and subsequent treatment of the generated bis-lithiated anilides 2 with aromatic aldehydes. Next, the 3-arylphthalides 3 were reduced [LiBH4] to phthalanes 5 and then, via reductive metallation [Li/C10H8] and reaction of the generated bis-lithiated species 6 with dimethylformamide, 3-hydroxy-4-arylisochromans 7 were produced. In the final step the isochromans 7 were treated with 1-methoxy-1-trimethylsilyloxyethene in the presence of titanium tetrachloride and furnished 4-arylisochromans-3-acetic acid methyl esters 8 as trans stereoisomers (Ψ-e/e).