869110-69-0

Upstream product

• 35229-21-1 Boc-Tyr(Bzl)-NH₂ 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 27513-44-6 N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester 
• 100-44-7 benzyl chloride 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 73504-43-5 2-amino-3-(4-benzyloxyphenyl)propionamide 

Downstream Products

• 869110-66-7 Hexadecanoic acid (R)-2-(benzyloxy-{4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester 
• 869110-65-6 Hexadecanoic acid (R)-2-(benzyloxy-{4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-phosphanyloxy)-1-hexadecanoyloxymethyl-ethyl ester 
• 869110-67-8 Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester 
• 869110-68-9 Hexadecanoic acid (R)-2-({4-[(S)-2,3-bis-(bis-carboxymethyl-amino)-propyl]-phenoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester 
• 869110-64-5 {[2-(bis-tert-butoxycarbonylmethyl-amino)-1-(4-hydroxy-benzyl)-ethyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Mn(II) Complex of Lipophilic Group-Modified Ethylenediaminetetraacetic Acid (EDTA) as a New Hepatobiliary MRI Contrast Agent

Liver-specific contrast agents (CAs) can improve the Magnetic resonance imaging (MRI) detection of focal and diffuse liver lesions by increasing the lesion-to-liver contrast. A novel Mn(II) complex, Mn-BnO-TyrEDTA, with a lipophilic group-modified ethylenediaminetetraacetic acid (EDTA) structure as a ligand to regulate its behavior in vivo, is superior to Gd-EOB-DTPA in terms of a liver-specific MRI contrast agent. An MRI study on mice demonstrated that Mn-BnO-TyrEDTA can be rapidly taken up by hepatocytes with a combination of hepatobiliary and renal clearance pathways. Bromosulfophthalein (BSP) inhibition imaging, biodistribution, and cellular uptake studies confirmed that the mechanism of hepatic targeting of Mn-BnO-TyrEDTA is the hepatic uptake of the amphiphilic anion contrast agent mediated by organic anion transporting polypeptides (OATPs) expressed by functional hepatocytes.

Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein

An artificial phospholipid, possessing saturated alkyl chains as a membrane anchor and protein recognition site as well as an Fe(III)-EDTA moiety as a protein cleavable polar head group, was designed and synthesized based on the amidite method for the pur