869115-81-1Relevant academic research and scientific papers
Synthesis and aromatisation of cyclic enediyne-containing amino acids
Kaiser, Jasper,Van Esseveldt, Bart C. J.,Segers, Margot J. A.,Van Delft, Floris L.,Smits, Jan M. M.,Butterworth, Sam,Rutjes, Floris P. J. T.
experimental part, p. 695 - 705 (2009/06/19)
A series of cyclic enediyne-containing amino acids with ring sizes varying from 10 to 12 atoms have been prepared starting from propargylglycine and homopropargylglycine. Their reactivity towards Bergman cyclisation under elevated temperatures has been ex
The synthesis and evaluation of 10- and 12-membered ring benzofused enediyne amino acids
Du, Yanming,Creighton, Christopher J.,Yan, Zhengyin,Gauthier, Diane A.,Dahl, John P.,Zhao, Boyu,Belkowski, Stanley M.,Reitz, Allen B.
, p. 5936 - 5948 (2007/10/03)
The enediyne moiety is a versatile functional group found in natural anticancer and anti-infective agents, undergoing the Bergman cyclization reaction to afford a diradical which cleaves double-stranded DNA. We have incorporated the enediyne group into 10
