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3-Ethyl-2,5-pyrazinediethanol, also known as Clavulanate Potassium EP Impurity C, is a chemical compound derived from Clavulanic acid (C563750). It is an impurity found in the production process of Clavulanic acid, which is a β-lactamase inhibitor used in combination with penicillin antibiotics to enhance their effectiveness.

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  • 86917-74-0 Structure
  • Basic information

    1. Product Name: 3-Ethyl-2,5-pyrazinediethanol
    2. Synonyms: 3-Ethyl-2,5-pyrazinediethanol;3-Ethyl-2,5-bis(2-hydroxyethyl)pyrazine;Clavulanic acid iMpurity C;Clavulanate Potassium EP Impurity C;Clavulanic Impurity C;Potassium Clavulanate impurity C;2,2'-(3-ethylpyrazine-2,5-diyl)diethanol
    3. CAS NO:86917-74-0
    4. Molecular Formula: C10H16N2O2
    5. Molecular Weight: 196.24624
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycless;Impurities
    8. Mol File: 86917-74-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 334.5±37.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.158±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Refrigerator
    8. Solubility: Chloroform (Slightly), Methanol (Slightly)
    9. PKA: 14.24±0.10(Predicted)
    10. CAS DataBase Reference: 3-Ethyl-2,5-pyrazinediethanol(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-Ethyl-2,5-pyrazinediethanol(86917-74-0)
    12. EPA Substance Registry System: 3-Ethyl-2,5-pyrazinediethanol(86917-74-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 86917-74-0(Hazardous Substances Data)

86917-74-0 Usage

Uses

Used in Pharmaceutical Industry:
3-Ethyl-2,5-pyrazinediethanol is used as an impurity in the production of Clavulanic acid for its role in enhancing the effectiveness of penicillin antibiotics. It is important to monitor and control the levels of this impurity to ensure the safety and efficacy of the final product.
Additionally, high concentrations of Clavulanic acid, but not its degradation products, have been found to decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus. This information can be useful for optimizing the production process and improving the yield of Clavulanic acid.

Check Digit Verification of cas no

The CAS Registry Mumber 86917-74-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,9,1 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 86917-74:
(7*8)+(6*6)+(5*9)+(4*1)+(3*7)+(2*7)+(1*4)=180
180 % 10 = 0
So 86917-74-0 is a valid CAS Registry Number.

86917-74-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[6-ethyl-5-(2-hydroxyethyl)pyrazin-2-yl]ethanol

1.2 Other means of identification

Product number -
Other names 3-Ethyl-2,5-pyrazinediethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86917-74-0 SDS

86917-74-0Downstream Products

86917-74-0Relevant articles and documents

Studies on the Hydrolysis of Clavulanic Acid

Finn, Malcolm J.,Harris, Michael A.,Hunt, Eric,Zomaya, Iskander I.

, p. 1345 - 1349 (2007/10/02)

1-Amino-4-hydroxybutan-2-one (14) has been identified as one of the major products from the hydrolysis of clavulanic acid in acidic, alkaline, or neutral solution.In alkaline or neutral solution, the amino ketone (14) is converted into other products, including two pyrazines, 2,5-bis(2-hydroxyethyl)pyrazine and 3-ethyl-2,5-bis(2-hydroxyethyl)pyrazine.A rationale for the formation of these products is discussed.

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