869189-67-3Relevant academic research and scientific papers
Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1′ permutations
Burns, David M.,He, Chunhong,Li, Yanlong,Scherle, Peggy,Liu, Xiangdong,Marando, Cindy A.,Covington, Mayanne B.,Yang, Gengjie,Pan, Max,Turner, Sharon,Fridman, Jordan S.,Hollis, Gregory,Vaddi, Kris,Yeleswaram, Swamy,Newton, Robert,Friedman, Steve,Metcalf, Brian,Yao, Wenqing
, p. 560 - 564 (2008/09/16)
A series of β-sulfonamide piperidine hydroxamates were prepared and shown to be potent inhibitors of the human epidermal growth factor receptor-2 (HER-2) sheddase with excellent selectivity against MMP-1, -2, -3, and -9. This was achieved by exploiting su
Hydroxamic acid derivatives as metalloprotease inhibitors
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Page/Page column 29, (2010/02/14)
The present invention provides compounds of Formula I or II: salt form or prodrug thereof, wherein variables are defined herein, that are modulators of metalloproteases such as matrix metalloproteases (MMPs) and ADAMs. The compounds or compositions descri
