869209-23-4

Upstream product

• 869209-22-3 1-bromo-4-((Z)-3-bromo-1-iodopropenyl)benzene 
• 317319-10-1 methyl (4-hydroxy-2-methylphenoxy)acetate 
• 452296-51-4 (Z)-3-(4-bromophenyl)-3-iodoprop-2-en-1-ol 
• 37614-58-7 3-(4-bromophenyl)prop-2-yn-1-ol 
• 1122-91-4 4-bromo-benzaldehyde 
• 136350-66-8 1-bromo-4-(2,2-dibromovinyl)benzene 

Downstream Products

• 869209-24-5 (Z)-[4-[3-(4-bromophenyl)-5-phenylpent-2-en-4-ynyloxy]-2-methylphenoxy]acetic acid methyl ester 
• 942596-73-8 methyl (Z)-[4-[3-(benzo[b]thiophen-2-yl)-3-(4-bromophenyl)allyloxy]-2-methylphenoxy]-acetate 

Relevant academic research and scientific papers

E/Z Isomerization of 3,3-disubstituted allylic thioethers

Allylic thioethers of the general structure 1 underwent E/Z isomerization during both basic and acidic hydrolysis of the ester moiety at the remote end of the molecule. The isomerization was dependent on the substitution of the allylic moiety. The presenc

Novel selective PPARδ agonists: Optimization of activity by modification of alkynylallylic moiety

Y-shaped molecules bearing alkynylallylic moieties were found to be potent and selective PPARδ activators. The alkynylallylic moiety was synthesized from alkyn-1-ols by hydroalumination followed by a cross-coupling reaction. Series of active compounds 6 w

NOVEL COMPOUNDS, THEIR PREPARATION AND USE

Novel compounds of the general formula (I), the use of these compounds as phar- maceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.

NOVEL COMPOUNDS, THEIR PREPARATION AND USE

Novel compounds of the general formula (I), in which the variables are as defined in claim 1, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compound