86930-90-7

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 821-41-0 5-Hexen-1-ol 
• 65596-92-1 6-(4-nitrophenyl)-hexanoic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 

Downstream Products

• 1025820-14-7 6-(4-nitrophenyl)hexyl bromide 
• 80258-67-9 6-(4-Nitro-phenyl)-hexylamine 
• 1613708-67-0 C₁₃H₁₉NO₅S 
• 1027236-77-6 3-Cyano-3-hydroxy-4-[6-(4-nitro-phenyl)-hexylsulfanyl]-butyric acid methyl ester 
• 1028274-42-1 4-[6-(4-Nitro-phenyl)-hexylsulfanyl]-3-oxo-butyric acid methyl ester 

Relevant academic research and scientific papers

CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY

This invention provides compounds of the formula I: and their pharmaceutically acceptable salts, useful as sodium channel blockers, compositions containing the same, therapeutic methods and uses for the same and processes for preparing the same.

ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme

ATP-citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Inhibitors of the enzyme represent a potentially novel class of hypolipidemic agent, which are anticipated to have combined hypocholesterolemic and hypotriglyceridemic properties. A series of 2-substituted butanedioic acids have been designed and synthesized as inhibitors of the enzyme. The best compounds, 58, 68, 71, 74 have reversible K(i)'s in the 1-3 μM range against the isolated rat enzyme. As representative of this compound class, 58, has been shown to exert its inhibitory action through a mainly competitive mechanism with respect to citrate and a noncompetitive one with respect to CoA. None of the inhibitors were able to inhibit cholesterol and/or fatty acid synthesis in HepG2 cells. This has been attributed to the adverse physicochemical properties of the molecules leading to a lack of cell penetration. Despite this, a lead structural class of compound has been identified with the potential for modification into potent, cell-penetrant, and efficacious inhibitors of ATP- citrate lyase.

4-(Substituted alkyl)-N-(1,3-dithiolan-2-ylidene(aniline

N-(1,3-dithiolan-2-ylidene)-4-alkylanilines having a hydroxy, alkoxy or alkanoyloxy substituent on the alkyl group are useful as anti-inflammatory agents, as analgesic agents and as antiasthmatic agents. The compounds involved can be prepared by the reaction of an appropriate 4-alkylaniline with a methyl(1,3-dithiolan-2-ylidene)sulfonium salt or with carbon disulfide and ethylene dibromide in the presence of a base.