869308-47-4

Upstream product

• 875-74-1 (R)-phenylglycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7103-09-5 4-but-1-enylmagnesium bromide 
• 137284-11-8 (2R)-2-N-(tert-butoxycarbonyl)amino-2-phenylethanal 

Downstream Products

• 869308-49-6 3-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 869308-50-9 3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 763105-94-8 (2R,3R)-1-(tert-butyloxycarbonyl)-3-hydroxy-2-phenylpiperidine 
• 869308-48-5 [2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-hex-5-enyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

A stereoselective route to cis-2-phenyl-3-piperidinol

Enantiopure cis-2-phenyl-3-piperidinol is a commonly used synthon for the obtention of a potent class of neurokinin substance P receptor antagonists. Starting from (R)-phenylglycine, the present report describes an efficient route for the stereoselective