869334-18-9Relevant academic research and scientific papers
Titanium(IV)-mediated conversion of carboxamides to amidines and implications for catalytic transamidation
Kissounko, Denis A.,Guzei, Ilia A.,Gellman, Samuel H.,Stahl, Shannon S.
, p. 5208 - 5210 (2005)
Cp*-ligated imidotitanium(IV) complexes, Cp*TiCl(NR)(py)Cl (R = tBu (5a), PhCH2 (5b), n-C5H11 (5c), p-MeC 6H4 (5d), p-MeOC6H4 (5e)), react with tertiary and secondary carboxamides to yield amidines, a result that is in contrast with previously reported titanium-catalyzed transamidation reactions. The tertiary amide dimethylacetamide reacts directly with the imidotitanium(IV) fragment, whereas the secondary amide phenylacetamide forms an amidate adduct, {(η5-C5Me5)TiCl[OC(Me)NPh]2} (10), which undergoes subsequent reaction with exogenous amine.
