869370-34-3Relevant academic research and scientific papers
Synthesis of new furo[2,3-d]pyrimidines and pyrimido[4′,5′:4,5] furo[2,3-d]pyrimidines
Moneam, Maisa I. Abdel,Geies, Ahmed A.,El-Naggar, Galal M.,Mousa, Soliman M.
, p. 1357 - 1366 (2007/10/03)
Sodium salt of 4-hydroxy-6-methyl-2-phenylpyrimidine-5-carbonitrile (3) was subjected to alkylation with different α-halo compounds, where the corresponding O-alkylated products 4a-g were obtained. Ring closure of the O-alkylated product 4a-c performed using sodium ethoxide in refluxing ethanol afforded furo[2,3-d]pyrimidines 5a-c. The latter compounds on reaction with a variety of reagents gave other new furopyrimidines as well as a number of furodipyrimidines.
