86941-30-2Relevant academic research and scientific papers
2-Azonia-Cope Rearrangement in N-Acyliminium Cyclizations
Ent, Hugo,Koning, Henk de,Speckamp, W. Nico
, p. 1687 - 1691 (2007/10/02)
Acid-induced cyclizations of N-(2'-aryl-3'-butenyl)-5-hydroxy-2-pyrrolidinones to give indolizidine and pyrrolizidine derivatives were studied.The mechanism of the pyrrolizidine formation, proceeding via 2-azonia-Cope rearrangement of the initially formed
THE 2-AZA-COPE N-ACYLIMINIUM CYCLIZATION
Ent, Hugo,Koning, Henk de,Speckamp, W. Nico
, p. 2109 - 2112 (2007/10/02)
The 2-aza-Cope N-acyliminium ring closure is shown to proceed in a stereoselective fashion via the primary N-acyliminium intermediate 1B.The latter ion can also be generated from the open hydroxymethyllactam 6b.
