869465-13-4Relevant academic research and scientific papers
Synthesis of trifluoromethyl- A nd ester group-substituted α-carbolines via iron-catalyzed tandem cyclization reaction
Xu, Yumin,Chen, Xiaoqian,Gao, Yiqin,Yan, Zicong,Wan, Changfeng,Liu, Jin-Biao,Wang, Zhiyong
, p. 4354 - 4364 (2020/04/10)
An efficient approach to prepare trifluoromethyl-α-carbolines and ester group-substituted α-carbolines via the tandem cyclization reaction of 2-(2-aminophenyl)acetonitriles and trifluoromethyl 1,3-diones or ,?-unsaturated α-ketoesters was reported. The tr
Facile synthesis of fluorinated benzofuro- and benzothieno[2,3-b]pyridines, α-carbolines and nucleosides containing the α-carboline framework
Iaroshenko, Viktor O.,Wang, Yan,Zhang, Biao,Volochnyuk, Dmitriy,Sosnovskikh, Vyacheslav Ya.
experimental part, p. 2393 - 2402 (2010/01/16)
Fluorinated benzofuro[2,3-b]pyridines, benzothieno[ 2,3-b]pyridines and 9H-pyrido[2,3-b]indoles (α-carbolines) were synthesized via regiospecific pyridine core annulation of a number of fluoro-containing 1,3-CCC- dielectrophiles to benzofuran-2-amine, benzothiophen-2-amine and 1H-indol-2-amine. Based on the 2,4-bis(trifluoromethyl)-9H-pyrido[2,3-b]indole thus synthesized, the preparative approach towards a set of nucleosides and nucleoside mimetics bearing the α-carboline framework was elaborated. Georg Thieme Verlag Stuttgart.
