869465-18-9Relevant academic research and scientific papers
A practical synthetic route to benzofuro[2,3-b] pyridine and trifluoromethyl-α-carbolines
Iaroshenko, Viktor O.,Groth, Ulrich,Kryvokhyzha, Nadiya V.,Obeid, Samra,Tolmachev, Andrei A.,Wesch, Thomas
, p. 343 - 346 (2008)
In situ generated benzofuran-2-amine reacts with 1,3-CCC-dielectrophiles, such as CF3-containing β-diketones, 3-formylchromone, methyl-2,4-dioxopentanoate and pentafluorobenzaldehyde, and the reaction leads to the formation of benzofuro[2,3-b]pyridine ring system. By using a similar approach 4-trifluoromethyl-α-carbolines were synthesized starting from indole-2-amine. Georg Thieme Verlag Stuttgart.
Facile synthesis of fluorinated benzofuro- and benzothieno[2,3-b]pyridines, α-carbolines and nucleosides containing the α-carboline framework
Iaroshenko, Viktor O.,Wang, Yan,Zhang, Biao,Volochnyuk, Dmitriy,Sosnovskikh, Vyacheslav Ya.
experimental part, p. 2393 - 2402 (2010/01/16)
Fluorinated benzofuro[2,3-b]pyridines, benzothieno[ 2,3-b]pyridines and 9H-pyrido[2,3-b]indoles (α-carbolines) were synthesized via regiospecific pyridine core annulation of a number of fluoro-containing 1,3-CCC- dielectrophiles to benzofuran-2-amine, benzothiophen-2-amine and 1H-indol-2-amine. Based on the 2,4-bis(trifluoromethyl)-9H-pyrido[2,3-b]indole thus synthesized, the preparative approach towards a set of nucleosides and nucleoside mimetics bearing the α-carboline framework was elaborated. Georg Thieme Verlag Stuttgart.
