869494-75-7Relevant academic research and scientific papers
Solid-phase, multicomponent reactions of methyleneaziridines: Synthesis of 1,3-disubstituted propanones
Margathe, Jean-Francois,Shipman, Michael,Smith, Stephen C.
, p. 4987 - 4990 (2005)
(Chemical Equation Presented) Polymer-supported methyleneaziridines undergo ring opening by Grignard reagents under copper catalysis to yield metalloenamines which are alkylated in situ to yield ketimines. Filtration and washing of these Merrifield resin-bound intermediates prior to hydrolysis provides the corresponding 1,3-disubstituted propanones in a high state of purity without recourse to column chromatography.
