86954-05-4Relevant academic research and scientific papers
First synthesis process of octahydro-5H-pyrrolo[1,2-A][1,4]diazepin-5-one
-
, (2019/01/05)
The invention relates to a first synthesis process of octahydro-5H-pyrrolo[1,2-A][1,4]diazepin-5-one. The process comprises the steps of subjecting DL-proline, which serves as a starting material, tocarboxyl reduction so as to obtain pyrrolidin-2-methanol
A library of conformationally restricted saturated heterocyclic sulfonyl chlorides
Zhersh, Sergey,Buryanov, Volodymyr V.,Karpenko, Oleksandr V.,Grygorenko, Oleksandr O.,Tolmachev, Andrey A.
scheme or table, p. 3669 - 3674 (2011/12/16)
An approach to the synthesis of conformationally restricted saturated heterocyclic sulfonyl chlorides is described. Being guided by the principle of diversity-oriented conformational restriction, a mini-library of saturated heterocyclic sulfonyl chlorides
Synthesis of alkaloid analogues from β-amino alcohols by β-fragmentation of primary alkoxyl radicals
Boto, Alicia,Hernandez, Dacil,Hernandez, Rosendo,Montoya, Adriana,Suarez, Ernesto
, p. 325 - 334 (2007/10/03)
The fragmentation of primary alkoxyl radicals is usually a minor process with respect to hydrogen abstraction and other competing reactions. However, when β-amino alcohols were used as substrates, the scission proceeded in good to excellent yields and no side reactions were observed. The fragmentation can be coupled with an allylation or alkylation reaction, to give alkaloid analogues and functionalized nitrogen heterocycles. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
Src kinase inhibitor compounds
-
, (2008/06/13)
Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.
Efficient and chemoselective cleavage of TBS ethers by a sub-stoichiometric amount of decaborane
Jeong, Yeon Joo,Lee, Ji Hee,Park, Eun Soo,Yoon, Cheol Min
, p. 1223 - 1225 (2007/10/03)
TBS ethers od aliphatic alcohols in THF-MeOH (or methanol) were deprotected chemoselectively to the corresponding alcohols using a sub-stoichiometric amount of decaborane at rt under nitrogen in high yields.
Angiotensin II antagonists
-
, (2008/06/13)
This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.
Angiotensin II antagonist intermediates
-
, (2008/06/13)
This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.
Benzazepine and benzothiazepine derivatives
-
, (2008/06/13)
Vasodilating activity is exhibited by compounds having the formula STR1 wherein X can be --S--or --CH2 --; and R2 is STR2 depending upon the definition of X.
A Synthesis of a New Type of Alkoxycarbonylating Reagents from 1,1-Bis Carbonate (BTBC) and Their Reactions
Takeda, Kazuyoshi,Tsuboyama, Kanoko,Hoshino, Mitsuho,Kishino, Miyuki,Ogura, Haruo
, p. 557 - 560 (2007/10/02)
1,1'-Bis carbonate (BTBC) was prepared from 1-hydroxy-6-trifluoromethylbenzotriazole and trichloromethyl chloroformate (trichloromethyl carbonochloridate).The reaction of BTBC and alcohols afforded the corresponding acti
p-ANISYL GROUP: A VERSATILE PROTECTING GROUP FOR PRIMARY ALCOHOLS
Fukuyama, Tohru,Laird, Alison A.,Hotchkiss, Lia M.
, p. 6291 - 6292 (2007/10/02)
A primary alcohol can be protected as a highly stable p-anisyl ether, which undergoes mild oxidative deprotection by ceric ammonium nitrate.
