86961-47-9Relevant academic research and scientific papers
PROTECTION OF THE TRYPTOPHAN INDOLE RING IN PEPTIDE SYNTHESIS. USE OF A NEW DERIVATIVE, Nin-2,2,2-TRICHLOROETHOXYCARBONYLTRYPTOPHAN
Kiso, Yoshiaki,Inai, Masatoshi,Kitagawa, Kouki,Akita, Tadashi
, p. 739 - 742 (2007/10/02)
The 2,2,2-trichloroethoxycarbonyl (Troc) group attached at the Nin function of tryptophan by acylation with Troc-Cl in the presence of a catalytic amount of tetra-n-butylammonium hydrogensulfate can be quantitatively removed either by cadmium dust in acetic acid or under basic conditions, e. g., hydrazine hydrate and NaOH, but is resistant to strong acidic conditions.
