869631-11-8

Basic information

• Product Name: O-Desethyl Candesartan Cilexetil
• Synonyms: O-Desethyl Candesartan Cilexetil ;2,3-Dihydro-2-oxo-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-benziMidazole-4-carboxylic Acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl Ester;Candesartan Cilexetil EP IMpurity B;1-(Cyclohexyloxycarbonyloxy)ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl) methyl)-2-hydroxy-1H-benzo[d]imidazole-7-carboxylate;Candesartan Impurity 1
• CAS NO: 869631-11-8
• Molecular Formula: C₃₁H₃₀N₆O₆
• Molecular Weight: 581.59856
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 869631-11-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 237-239?C (dec.)
• Appearance: /
• Density: 1.437g/cm³
• Refractive Index: 1.677
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 4.16±0.10(Predicted)
• CAS DataBase Reference: O-Desethyl Candesartan Cilexetil(CAS DataBase Reference)
• NIST Chemistry Reference: O-Desethyl Candesartan Cilexetil(869631-11-8)
• EPA Substance Registry System: O-Desethyl Candesartan Cilexetil(869631-11-8)

Safety Data

• Hazardous Substances Data: 869631-11-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 869631-11-8 differently. You can refer to the following data:
1. O-Desethyl Candesartan Cilexetil (Candesartan Cilexetil EP Impurity B) is used for the preparation of Candesartan Cilexetil (CAT# C175580), which is an antihypertensive. It may be obtained as a degradation product of Candesartan Cilexetil in liquid chromatography studies.
2. O-Desethyl Candesartan Cilexetil can be used for the preparation of Candesartan cilexetil.

InChI:InChI=1/C31H30N6O6/c1-19(42-31(40)43-22-8-3-2-4-9-22)41-29(38)25-12-7-13-26-27(25)37(30(39)32-26)18-20-14-16-21(17-15-20)23-10-5-6-11-24(23)28-33-35-36-34-28/h5-7,10-17,19,22H,2-4,8-9,18H2,1H3,(H,32,39)(H,33,34,35,36)

Upstream product

• 145040-37-5 candesartan cilexetil 
• 170791-09-0 cilexetil trityl candesartan 

Relevant articles and documents

Identification, synthesis and structural determination of some impurities of candesartan cilexetil

All principal candesartan cilexetil impurities and/or degradation products were synthesized and identified. The differentiation of N-l and N-2 ethylated candesartan cilexetil derivatives was performed using ID and 2D NMR experiments. The influence of the magnetic field on the resolution and sensitivity of NMR experiments is shown. Selective hydrolysis of these compounds then provided corresponding producrs of hydrolysis of the ethoxy group. Institute of Organic Chemistry and Biochemistry.

STABLE MICRONIZED CANDESARTAN CILEXETIL AND METHODS FOR PREPARING THEREOF

The invention encompasses sable candesartan cilexetil of fine particle size, wherein desethyl-candesartan (desethyl-CNS) within the stable candesartan cilexetil does not increase to more than about 0.1%w/w by HPLC relative to the initial amount of candesartan cilexetil, when the stable candesartan cilexetil is maintained at a temperature of about 550°C for at least 2 weeks, methods of making the same and pharmaceutical compositions thereof.