869649-93-4

Upstream product

• 40350-83-2 (2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 109953-95-9 tert-butyl (2S,4R)-4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 

Downstream Products

• 1283145-81-2 ((2S,4R)-4-(benzyloxy)-1-(4-bromophenyl)pyrrolidin-2-yl)methanol 
• 1283145-82-3 2-((2R,4R)-4-(benzyloxy)-1-(4-bromophenyl)pyrrolidin-2-yl)acetonitrile 
• 1283145-83-4 ((2S,4R)-4-(benzyloxy)-1-(4-bromophenyl)pyrrolidin-2-yl)methyl methanesulfonate 
• 1283145-84-5 2-((2R,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile 
• 1283145-86-7 2-((2S,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt 
• 1283142-41-5 2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt 

Relevant academic research and scientific papers

PYRROLIDINE GPR40 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE

Provided herein are pyrrolotriazine compounds for treatment of Aurora kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.