869671-80-7Relevant academic research and scientific papers
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277
Zhou, Lin,Alker, Andre,Ruf, Armin,Wang, Xiaofang,Chiu, Francis C.K.,Morizzi, Julia,Charman, Susan A.,Charman, William N.,Scheurer, Christian,Wittlin, Sergio,Dong, Yuxiang,Hunziker, Daniel,Vennerstrom, Jonathan L.
, p. 1555 - 1558 (2008/12/22)
The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridgehead carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.
Spiro and dispiro 1,2,4-trioxolane antimalarials
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, (2008/06/13)
A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the
