86970-23-2Relevant academic research and scientific papers
RORγ MODULATORS
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, (2015/03/28)
Described are RORγ modulators of the formula (I), or pharmaceutically acceptable salts thereof, wherein all substituents are defined herein. The invention includes stereoisomeric forms of the compounds of formula I, including stereoisomerically-pure, scalemic and racemic form, as well as tautomers thereof. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
Discovery and SAR of hydantoin TACE inhibitors
Yu, Wensheng,Guo, Zhuyan,Orth, Peter,Madison, Vincent,Chen, Lei,Dai, Chaoyang,Feltz, Robert J.,Girijavallabhan, Vinay M.,Kim, Seong Heon,Kozlowski, Joseph A.,Lavey, Brian J.,Li, Dansu,Lundell, Daniel,Niu, Xiaoda,Piwinski, John J.,Popovici-Muller, Janeta,Rizvi, Razia,Rosner, Kristin E.,Shankar, Bandarpalle B.,Shih, Neng-Yang,Arshad Siddiqui,Sun, Jing,Tong, Ling,Umland, Shelby,Wong, Michael K.C.,Yang, De-yi,Zhou, Guowei
scheme or table, p. 1877 - 1880 (2010/07/04)
We disclose inhibitors of TNF-α converting enzyme (TACE) designed around a hydantoin zinc binding moiety. Crystal structures of inhibitors bound to TACE revealed monodentate coordination of the hydantoin to the zinc. SAR, X-ray, and modeling designs are d
HYDANTOIN DERIVATIVES FOR USE AS TACE AND AGGRECANASE INHIBITORS
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Page/Page column 57, (2010/02/14)
Hydantoin derivatives of formula (I) that are useful in the inhibition of metalloproteinases and in particular in the inhibition of TNF-α Converting Enzyme (TACE), aggrecanase or the combination thereof.
Synthesis of Aminomethyl-Substituted Cyclic Imide Derivatives for Evaluation as Anticonvulsants
Stratford, Eugene S.,Curley, Robert W.
, p. 1463 - 1469 (2007/10/02)
A series of aminomethyl-substituted cyclic imides (II) based on the 2,5-pyrrolidinedione (X = CH2, succinimide) and 2,4-imidazolidinedione (X = NH, hydantoin) ring systems have been prepared.The compounds were designed on the basis of a potential interact
