869736-88-9

Upstream product

• 391200-37-6 t-butyl (2-hydroxy-1-hydroxymethyl-1-methyl)ethylcarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 391678-23-2 (2R)-tert-butoxycarbonylamino-3-n-hexanoyloxy-2-methyl-1-propanol 
• 859232-95-4 hexanoic acid 2-tert-butoxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester 

Relevant academic research and scientific papers

Enzymatic desymmetrization of 2-amino-2-methyl-1,3-propanediol: Asymmetric synthesis of (S)-N-Boc-N,O-isopropylidene-α-methylserinal and (4R)-methyl-4-[2-(thiophen-2-yl)ethyl]oxazolidin-2-one

We report herein, the novel enzymatic desymmetrization of 2-tert-butoxycarbonylamino-2-methyl-1,3-propanediol 1. This method makes it possible to prepare (S)-N-Boc-N,O-isopropylidene-α-methylserinal 3, which is a chiral building block for the synthesis of a variety of α-substituted alanine derivatives. Moreover, optically active (4R)-methyl-4-[2-(thiophen-2- yl)ethyl]oxazolidin-2-one 4, one of the key intermediates in the synthesis of a novel immunosuppressant, has been prepared by this methodology.