869802-28-8

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 2365-48-2 Methyl thioglycolate 
• 824-94-2 p-methoxybenzyl chloride 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 635731-99-6 2-bromo-3-cyano-4-(4'-methoxybenzyloxy)pyridine 

Downstream Products

• 869802-31-3 9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one 
• 869802-30-2 9-(4'-methoxybenzyloxy)-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one 
• 903570-83-2 9-(trifluoromethanesulfonyl)-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one 
• 903570-82-1 4-(4'-methoxybenzyloxy)-5-(dimethylaminomethyleneamino)thieno[8,9-b]pyridine-6-carboxylic acid methyl ester 

Relevant academic research and scientific papers

ANTAGONISTS OF THE MGLU RECEPTOR AND USES THEREOF

The present invention discloses compounds of general formula (I) wherein X1-X4 and R1-R3 are as defined in the description. The present invention also discloses methods of treatment for pain, neurodegeneration and convulsive states in a host mammal in need thereof, and pharmaceutical compositions including those compounds.

Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists

SAR (structure-activity relationship) studies of triazafluorenone derivatives as potent mGluR1 antagonists are described. The triazafluorenone derivatives are non-amino acid derivatives and noncompetitive mGluR1 antagonists that bind at a putative alloste