869845-24-9Relevant academic research and scientific papers
Synthesis and monoamine transporter affinity of new 2β-carbomethoxy- 3β-[aryl or heteroaryl]phenyltropanes
Tamagnan, Gilles,Alagille, David,Fu, Xing,Kula, Nora S.,Baldessarini, Ross J.,Innis, Robert B.,Baldwin, Ronald M.
, p. 217 - 220 (2007/10/03)
A series of 16 new 2β-carbomethoxy-3β-[aryl or heteroaryl]phenyltropane derivatives was synthesized and evaluated for binding to monoamine transporters. Most of the compounds exhibited nanomolar affinity for the serotonin transporter (SERT). Four compound
Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 (N-fluoroalkyl) labeled 2β-carbomethoxy-3β-(4′-(3- furyl)phenyl)-tropanes and -nortropanes: Candidate radioligands for in vivo imaging of the serotonin transporter with posi
Stehouwer, Jeffrey S.,Plisson, Christophe,Jarkas, Nachwa,Zeng, Fanxing,Voll, Ronald J.,Williams, Larry,Martarello, Laurent,Votaw, John R.,Tamagnan, Gilles,Goodman, Mark M.
, p. 7080 - 7083 (2007/10/03)
2β-Carbomethoxy-3β-(4′-(3-furyl)phenyl)nortropane (1) was synthesized along with the N-methyl (2), N-fluoroethyl (3), N-fluoropropyl (4), and N-fluorobutyl (5) derivatives. The binding affinity for each compound to the human serotonin, dopamine, and norep
