869857-95-4Relevant academic research and scientific papers
Stereoselective synthesis of (2S,3S,4R,5S)-5-methylpyrrolidine-3,4-diol derivatives that are highly selective α-L-fucosidase inhibitors
Moreno-Vargas, Antonio J.,Carmona, Ana T.,Mora, Federico,Vogel, Pierre,Robina, Inmaculada
, p. 4949 - 4951 (2005)
N-Phenylaminomethyl benzimidazolyl moieties attached at C-2 of (2S,3S,4R,5S)-5-methylpyrrolidine-3,4-diol increase the potency and selectivity of the inhibitory activity of these systems towards α-L-fucosidases. The Royal Society of Chemistry 2005.
Synthesis of novel pyrrolidine 3,4-diol derivatives as inhibitors of α-L-fucosidases
Moreno-Clavijo, Elena,Carmona, Ana T.,Vera-Ayoso, Yolanda,Moreno-Vargas, Antonio J.,Bello, Claudia,Vogel, Pierre,Robina, Inmaculada
scheme or table, p. 1192 - 1202 (2009/05/30)
The stereoselective synthesis of new 3,4-dihydroxypyrrolidine derivatives starting from D-mannose, D-ribose and L-fucose is presented. Two synthetic strategies employing organometallic addition to hemiacetalic sugars followed by selective nucleophilic dis
