869882-01-9

Upstream product

• 869881-98-1 2-[ethoxy-(4-methyl-benzyl)-phosphinoyloxy]-benzoic acid methyl ester 
• 104-82-5 4-Methylbenzyl chloride 
• 3762-25-2 diethyl 4-methylbenzylphosphonate 
• 129529-07-3 ethyl (4-methylbenzyl)phosphonochloridate 

Relevant academic research and scientific papers

Alkylation reactions of phosphachroman-2,4-diones and 4-hydroxy phosphacoumarins

Phosphachroman-2,4-dione and 4-alkoxyphosphacoumarin derivatives, phosphonic analogues of chromones and coumarins with potential biological activities, were synthesized in good yields through sequential base-catalyzed intramolecular cyclization of O-alkyl

Synthesis of a diverse series of phosphacoumarins with biological activity

(Chemical Equation Presented) We have developed a general and efficient approach to a diverse series of phosphacoumarins as analogues of coumarins with various biological activities, and the inhibitory activity of the synthesized phosphacoumarins against the enzyme SHP-1, a protein tyrosine phosphatases, was tested. Some of them showed moderate to good efficiency.