869884-03-7

Basic information

• Product Name: methyl 1-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylate
• Synonyms: methyl 1-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylate
• CAS NO: 869884-03-7
• Molecular Weight: 267.327
• Mol File: 869884-03-7.mol

Chemical Properties

• CAS DataBase Reference: methyl 1-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylate(869884-03-7)
• EPA Substance Registry System: methyl 1-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylate(869884-03-7)

Safety Data

• Hazardous Substances Data: 869884-03-7(Hazardous Substances Data)

Upstream product

• 63430-79-5 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester 
• 603-33-8 triphenylbismuthane 
• 46185-24-4 1,2,3,4-tetrahydroquinoline-2-carboxylic acid 
• 93-10-7 quinoline-2-carboxylic acid 

Relevant articles and documents

Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists

In the course of continuing efforts to develop potent and bladder-selective muscarinic M3 receptor antagonists, quinuclidin-3-yl 1-aryl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives and related compounds were designed as conformationally restricted analogues of quinuclidin-3-yl benzhydrylcarbamate (8). Binding assays with rat muscarinic receptor subtypes revealed that the quinuclidin-3-yl 1-aryl-1,2,3,4- tetrahydroisoquinoline-2-carboxylate derivatives showed high affinities for the M3 receptor, and selectivity for the M3 receptor over the M2 receptor. Of these derivatives, (+)-(1S,3'R)-quinuclidin-3'-yl 1-phenyl-l,2,3,4-tetrahydroisoquinoline-2-carboxylate monohydrochloride (9b) exhibited almost the same inhibitory activity against bladder contraction to that of oxybutynin (1), and more than 10-fold selectivity for bladder contraction versus salivary secretion, demonstrating that 9b may be useful for the treatment of symptoms associated with overactive bladder without having side effects such as dry mouth.