869891-41-8

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2,4-dihydroxy-6-methylpyrimidine-5-carboxylate is used as an intermediate in the synthesis of pharmaceuticals for its potential therapeutic benefits. Its anti-tumor, anti-inflammatory, and anti-microbial properties make it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, Methyl 2,4-dihydroxy-6-methylpyrimidine-5-carboxylate is utilized as an intermediate in the production of agrochemicals, contributing to the development of effective and innovative solutions for agricultural applications.
Used in Organic Chemistry Research:
Methyl 2,4-dihydroxy-6-MethylpyriMidine-5-carboxylate is also used in organic chemistry research as a key building block for the synthesis of various organic compounds, expanding the scope of chemical reactions and exploring new chemical entities with potential applications in different fields.

Upstream product

• 14205-39-1 methyl 3-aminocrotonate 
• 936020-16-5 3-amino-2-(ethoxycarbonyl-carbamoyl)-but-2-enoic acid methyl ester 
• 19617-43-7 ethoxycarbonylisocyanate 

Downstream Products

• 36745-93-4 2,4-dichloro-6-methyl-pyrimidine-5-carboxylic acid methyl ester 
• 1610853-00-3 N-[(4-chlorophenyl)-methyl]-4-ethylsulfanyl-6-methyl-2-morpholin-4-yl-pyrimidine-5-carboxylic acid amide 
• 869891-43-0 2-(2,6-diethyl-phenyl)-4-methoxy-6-methyl-pyrimidine-5-carboxylic acid methyl ester 
• 869887-83-2 4-[2-(2,6-diethylphenyl)-4-methoxy-6-methylpyrimidin-5-yl]heptan-4-ol 

Relevant academic research and scientific papers

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

SUBSTITUTED AMINO-ACRYLCARBOXAMIDES AS KCNQ2/3 MODULATORS

The invention relates to amino-arylcarboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

SUBSTITUTED AMINO-ARYLCARBOXAMIDES AS KCNQ2/3 MODULATORS

The invention relates to amino-arylcarboxamides of formula (I), to pharmaceutical compositions containing these compounds and also to these compounds for use In the treatment and/or prophylaxis of pain and further diseases and/or disorders.

NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES

[Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. [Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, -OW1, -SW1, -COW2, -NW3W4, -SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, -CO-Y, -SO2-Y -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.

4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES

4,5-disubstituted-2-arylpyrimidines of Formula (I) and Formula (II) are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I and II bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 4,5-disubstituted-2-arylpyrimidines, which are useful as probes for the localization of C5a receptors.