86994-33-4

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 607-71-6 4-methyl-2H-chromen-2-one 
• 86994-35-6 (Z)-tert-butyl 3-hydroxy-3-(2-hydroxycyclohexyl)-butyrate 
• 101597-15-3 4-(4-methoxyphenyl)-4-methylchroman-2-one 
• 86994-39-0 sodium (Z)-3-hydroxy-3-(2-hydroxycyclohexyl)butyrate 

Relevant academic research and scientific papers

Br?nsted acid promoted one-pot synthesis of 4-aryl-3,4-dihydrocoumarins

4-Aryl-3,4-dihydrocoumarins are a class of valuable molecules demonstrating attractive pharmaceutical and biological properties. In this paper, we designed a new and facile approach to synthesis of 4-aryl-3,4-dihydrocoumarin derivatives by Br?nsted acid c

Synthesis of 3-Hydroxy-3-cyclohexylbutyric Acid Derivatives. 2. Cyclic Analogues of Mevalonic Acid

The sodium salt of (Z)-3-hydroxy-3-(2-hydroxycyclohexyl)butyric acid (I) and its lactone (II) were prepared through the corresponding tert-butyl ester by hydrogenation, over Rh/Al2O3 catalyst, of the phenyl ring of tert-butyl 3-hydroxy-3-(2-hydroxyphenyl)butyrate (III). (Z)-3-Hydroxy-3-(2-methoxycyclohexyl)butyric acid was prepared similarly. (Z)-4-Methyloctahydro-2H-1-benzopyran-2-one was prepared by hydrogenation, over Rh/Al2O3 catalyst, of 4-methylcoumarine, prepared in turn from III by a one-pot procedure comprising hydrolysis, lactonization, and dehydration.The above compounds inhibit acetate incorporation in cholesterol and fatty acids in rat liver slices at 5 * 10-3 M, but they lack specific inhibitory activity on HMG-CoA reductase.